Description

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for four consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
Insmed is seeking a Scientist II, Histologist with deep expertise in histology, molecular pathology, and translational science to support our gene therapy research and development programs. This individual will apply specialized histological and molecular techniques to analyze and visualize the effects of therapeutic gene delivery and expression in tissue samples from both preclinical models and clinical studies.
The successful candidate will work at the interface of research and development-helping to define tissue-based biomarkers, assess biodistribution, and evaluate treatment-related effects that directly inform our clinical programs.

What You'll Do:

Sample Processing and Preparation

• Receive, accession, and verify tissue specimens from preclinical and/or clinical studies.
• Perform tissue fixation, processing, embedding, and sectioning (paraffin and frozen samples).
• Prepare high-quality tissue sections using microtomy and cryosectioning for downstream analysis.

Molecular & Specialized Staining Techniques

• Perform immunohistochemistry (IHC) and immunofluorescence (manual and automated) to detect therapeutic gene products, disease biomarkers, and cellular responses.
• Conduct in situ hybridization (ISH) techniques (e.g., FISH, RNAscope) to detect and localize specific DNA/RNA sequences in gene therapy studies.
• Apply routine and advanced histochemical stains (e.g., H&E) for morphological and pathology assessments.

Analysis, Quality Control, and Documentation

• Examine slides under a microscope to evaluate tissue integrity, therapeutic gene expression, and any treatment-related changes.
• Capture and analyze images using digital pathology and imaging software; quantify biomarker expression patterns and distribution.
• Maintain meticulous documentation of all procedures, results, and quality control measures in compliance with GDP/GLP standards.
• Contribute to the preparation of study reports, regulatory filings, and scientific publications.

Innovation & Method Development

• Develop and validate novel histology and molecular pathology protocols tailored for gene therapy applications.
• Partner with Translational Science and Computational Biology teams to integrate tissue-based findings with multi-omics and biomarker datasets.
• Identify and implement emerging technologies (e.g., spatial transcriptomics, multiplex imaging) to advance Insmed's translational capabilities.

Collaboration

• Work cross-functionally with Clinical Development, Translational Science, and Research to ensure histological findings align with program goals.
• Manage relationships with external CROs, collaborators, and academic labs for histology services and method transfers.

Who You Are:

Education: Bachelor's degree in Histology, Biology, Medical Laboratory Science, or related field required; advanced degree (M.S.) preferred.

Certification: HT(ASCP) or HTL(ASCP) certification strongly preferred.

Experience:

o 3-6+ years of histology experience in a research or clinical setting, ideally within biotechnology, pharmaceutical, or translational science environments.

o Demonstrated expertise in IHC, ISH, and advanced histology methods applied to gene therapy or molecular pathology.

o Familiarity with preclinical animal models, human tissue handling, and tissue-based biomarker discovery.

o Strong proficiency with imaging platforms and quantitative pathology software.

• Excellent communication, organizational, and teamwork skills.

• Ability to operate in a fast-paced, high-growth environment with strict adherence to quality and compliance standards.

Pay Range:
$104,000.00-137,800.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.